The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by. Abstract: Apium graveolens (celery) is an edible and traditionally medicinal plant worldwide, among others for the treatment of hypertension. Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic mean arterial blood pressure and heart rate in normotensive and hypertensive rats.

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Animal experiment using aortic rings with and without endothelium has been widely established. Mechanisms of ETinduced endothelial dysfunction.

Annals of the New York Academy of Sciences, 1: Herbs and spices most commonly used for treatment of hypertension Secondary metabolites of herbs and spices exhibit anti-hypertensive effects. The magnitude of the decrease was determined to be an average of 4. Aortic ring, Apium graveolensMedicinal plant, Vasorelaxant. As shown in Figure 6the effect of hexanic extracts on HR was significantly greater than those of methanolic and aqueous-ethanolic celery seed extracts.

Similarly, another meta-analysis on randomized, controlled trials also reported a significant decrease in SBP by 4. Commonly used antihypertensive plants with anti-proliferative activity.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

An ex vivo method was employed to assess graveoolens vasorelaxant activity. I ncreased blood pressure BP is one of the important risk factors for coronary heart disease, which is the largest cause of mortality in industrial countries.


Taking BP medications can cause side effects such as headache, dizziness, tachycardia, feeling tired, and sexual dysfunction. Moreover, both luteolin Xagorari et al.

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

American journal of physiology renal physiology, 1: This was explained by greater retention of n-butylphthalide, which has been identified as the source of celery’s flavor and aromatic odor Moghadam et al. Collectively, the teas prepared from Camellia sinensis are the most frequently consumed beverages and are second only to water, graveeolens Faria et al.

Dichloromethane extract from A. The study was reviewed and approved by the local institutional review board.

Constituents of goldthread also act by relaxing arterial tissues through endothelial-dependent and independent routes Affuso et al. The hypotensive effect of celery has been reported in in vivo animal studies.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Endothelium-independent vasorelaxant effects of hydroalcoholic extract from Nigella sativa seed in rat aorta: These limitations would be discussed in the second part of this review. In this first part of our review, we discussed the mechanisms of action of several plants that are most commonly used in the treatment or management of hypertension. Aged garlic extract reduces blood pressure in hypertensives: Other studies have also reported similar antioxidant activities of coriander Cioanca et al.


After stopping the treatment, the HR changed to and BPM, in group 3 and 6 at the end of week 9. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension.

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Regulation of Nrf2-an update. A key molecule that regulates oxidative stress in VSMCs is the transcription factor erythroid 2-related factor 2 Nrf2, or nuclear factor erythroid 2-like 2.

In addition to being a major player in the onset of diseases such as atherosclerosis, stroke, peripheral artery disease, heart failure, and coronary artery disease, hypertension can also lead hyperhension kidney damage, dementia, or blindness August, ; Freedman and Cohen, Yao Xue Xue Bao. Support Center Support Center.

Danshen’s endothelium-dependent relaxations occur via an NO-dependent mechanism Chan et al. Other reports also indicate that A.

Cardiovascular and metabolic effects of Berberine. We declare that we have no conflict of interest. J Pharmacol Exp Ther. Effects of black tea on blood pressure: Journal of ethnopharmacology, 83 3: This plant belongs to the family Asteraceae and has several common names: Inhibitory effects of EAEAg on the contraction and cumulative-contraction.

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