Erythema elevatum diutinum (EED) is a rare, chronic dermatosis that is characterized by red–violet to red–brown papules, plaques, and. Erythema elevatum diutinum (EED) is a chronic form of leukocytoclastic vasculitis consisting of violaceous, red-brown, or yellowish papules. Erythema elevatum diutinum. Authoritative facts about the skin from DermNet New Zealand.

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Pathophysiology Although the etiology of EED is unknown, circulating immune complexes, with repeated deposition, associated inflammation, and partial healing are thought to represent the underlying pathogenesis. See the DermNet NZ bookstore.

Eritema elevatum diutinum as a differential diagnosis of rheumatic diseases: case report.

None Conflict of interest: The majority of cases resolve spontaneously over a period of 5 to 10 years, but the disease can last up to 40 years. Infobox medical condition new Pages using infobox medical condition with unknown parameters All stub articles.

Please enter User Name Password Error: National Center for Biotechnology InformationU. Histologically, early lesions of erythema elevatum diutinum show leukocytoclastic vasculitis. It presents predominantly in males, in the fourth to sixth decade of life. There is still controversy about the eleatum of EED. No mortality due to EED has been reported. None Date of first submission: They typically are symmetrically distributed and favor acral and periarticular sites, specifically the extensor surfaces of the eleevatum, knees, ankles, hands, and fingers.


Other therapies erigema NSAIDs, niacinamide, tetracyclines, chloroquine, colchicine, and plasmapheresis.

Topical and intralesional corticosteroids may be helpful for mild cases, but systemic corticosteroids are rarely indicated. The disease can develop at any age but is more common in the fourth and sixth decades. Clinically is characterized by red, purple, brown or yelow papules, plaques or nodules.

Erythema elevatum diutinum

Consequently, even though the association of EED with HIV eelvatum is infrequent, laboratory investigation for this virus should be requested in conventional cases, and especially in cases of atypical and exacerbated clinical manifestations. Erythema elevatum diutinum in association with IgA monoclonal gammopathy: Home About Us Advertise Amazon.

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These lesions are usually symmetrically distributed on the extensor surfaces of the extremities. DermNet NZ does not provide an online consultation service. The severity of EED does not, however, appear to be dependent on the total paraprotein levels. StatPearls Publishing ; Jan. Fifteen days later, partial regression of the lesions was achieved, without any antiretroviral therapy yet prescribed. Sign up for our Email Newsletters. This cutaneous condition article is a stub.

Most importantly, some of the neutrophilic dermatoses, including EED, have been associated with underlying paraproteinemias monoclonal and polyclonal IgA gammopathies 7 and hematologic malignancies. Laboratory tests showed discrete leukopenia, while his hepatic and renal function and protein and immunoglobulin electrophoresis presented no abnormalities.

Nodules removed from hand.


Although the etiology of EED is unknown, circulating immune complexes, with repeated deposition, associated inflammation, and partial healing are thought to represent the underlying pathogenesis. Epidemiology EED is rare, with descriptions of only several hundred cases in the literature.

Paroxysmal hand hematoma Postcardiotomy syndrome Deep vein thrombosis Superficial thrombophlebitis Mondor’s disease Blueberry muffin baby Fibrinolysis syndrome. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.

On this occasion, antiretroviral therapy was begun. Extracellular cholesterol deposits may be observed elevatym the fibrotic tissue. Immune complex deposition results in complement activation, neutrophilic infiltration, and the release of destructive enzymes. Images hosted on other servers: CASE REPORT A year old male Caucasian patient, born and residing in Campinas, had diutinuj history of hyperchromic elsvatum, bilaterally located in the medial and lateral malleolar zone of the ankles and on the heels and dorsal aspect of the feet.

The cause of EED ekevatum not well understood, but it is thought to be secondary to immune complex deposition in dermal blood vessels, which results in complement fixation and subsequent inflammation.

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